The Role of Baobab in Controlling Oxidative Stress on induced diabetic Male Albino Rats

Abstract

This study has been conducted in order to  examine the effects of baobab on oxidative stress in a diabetic model. Including  seven groups,  involved 10 albino rat for each group  the first group is the control group that no treatment and positive group diabetic group which treated with alloxan was used to induce diabetes in the experimental group 100 mg/kg. Blood samples were taken to confirm diabetes, and after stabilization, the experimental group was distributed into subgroups. Different treatments, including baobab crude 500mg/kg , metformin 100 mg/kg, and combination(baobab 500 mg/kg + metformine 100 mg/kg) , were administered orally until day 30 . Kidney and liver samples isolated collected for histological  analysis. Statistical analysis using ANOVA and   tests was be performed, and the results was presented as mean ± SEM

 Baobab effectively reduced malondialdehyde MDA levels and increased total antioxidant status TAOS, indicating its potential as an antioxidant in managing oxidative stress associated with diabetes. Histological examination  showed changing  in liver tissue structure. Baobab has promising potential as a natural option for decrease the oxidative stress and preventing complications in diabetes.

In conclusion, Baobab, has antioxidant properties and has shown promise in managing oxidative stress In the context of rat diabetes, the application of baobab has demonstrated effective reductions in MDA levels, concurrent increases in TAOS, and notable enhancements in liver tissue structure. The utilization of baobab's crude plant form emerges as a potential natural strategy to bolster overall health and preempt complications linked to diabetes. However, it is imperative to underscore that a more comprehensive investigation is required to gain a thorough grasp of its therapeutic capabilities.