Protective Effect of Olive Leaves Extract on some physiological and biochemical parameters in Male Rats after the Administration of Paracetamol

Abstract

This study aimed to know the protective effect of olive leaf extract against the side effects of Paracetamol in male rats such as liver & renal functions  , antioxidant test  (MDA, GSH) s in male rats. The study was conducted in the animal house of the Veterinary Medicine College, Tikrit University during the period (1. Desember.2023 to 30. December.2023). 24 adult male rats were used in this study. They were divided into three groups each group consists of 8 rats. These group are G1 (control), G2 (Paracetamol 1000mg/kg.B.W), G3(Paracetamol 1000mg/kg.B.W,+ Olive leaves extract 500mg/kg.B.W.  Result of This study showed significantly increase (P≤0.05)  in  liver enzymes, MDA, Urea, creatinine and also a significant decrease in GSH parameter in G2 receiving (Paracetamol 1000mg/kg) after 30 days from treatment compared with control group but significantly  graduated decreased (P≤0.05) in Paracetamol + olive leaf extract treated G3 due to protective effect of OLE .However after treatment with the Paracetamol +OLE group detected a significant increase (P≤0.05) in GSH parameter compared to Paracetamol group. Conclusion: The OLE has a significant protective effect from Paracetamol on some side effects in the hematological and biochemical parameters the male rats