Comparative Evaluation of Anticoagulant Effects of Curcumin and Ginger Against Warfarin in Rat Models

Abstract

The rising demand for oral anticoagulants necessitates the investigation of novel alternatives, particularly in light of the limitations associated with Warfarin. Curcumin, the primary bioactive constituent of turmeric, exhibits significant anticoagulant properties, as evidenced by empirical studies indicating its ability to prolong clotting times and reduce thrombin activity, thereby presenting a potential breakthrough in thrombotic disorder management.underscoring the importance of this spice for enhanced quality of life. Material and method :The investigation involved 48 rats categorized into eight groups, with six rats allocated per group. The first group control, the second group cohort received warfarin, the third  with turmeric, the fourth with ginger, the fifth  with warfarin and curcumin , the sixth  with warfarin with ginger , the seventh with curucmin and ginger, and the eighth a combination of warfarin, turmeric, and ginger, to assess the anticoagulant and antiplatelet properties of ginger and curcumin in vivo, employing rat blood samples for comparative analysis against warfarin through various assays including Fibrinogen, Vitamin K, Fibrinogen Degradation Product, Prothrombin time, INR, APTT, bleeding time. Results :Findings revealed that the inclusion of turmeric and ginger enhances the efficacy of warfarin in lowering vitamin K levels while simultaneously prolonging prothrombin time, bleeding time, INR, and clotting duration. The research indicated that turmeric specifically influences fibrinolysis, whereas ginger affects thrombin time. Additionally, the study demonstrated that turmeric and ginger contribute to increased hemoglobin levels.   Conclusion: drawn from the research suggests that turmeric and ginger may serve as viable alternatives to warfarin when its adverse effects are unmanageable. The primary objective was to assess the anticoagulant effectiveness of turmeric and ginger in comparison to warfarin.