Reverse side effect of nifedipine on Leydig cells male rabbits in vitro by liposome containing nifedipine and sodium nitroprusside

Authors

  • Abdullah I. Al-Obeidi Dept. of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine, Tikrit University, Tikrit, Iraq Author
  • Waseem A. Hasan Dept. of basic science , College of Dentistry, Tikrit University, Tikrit, Iraq Author
  • Mohanad A. Al-Bayati Dept. of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine, Baghdad University, Baghdad, Iraq Author

DOI:

https://doi.org/10.25130/tjvs.1.2.8

Keywords:

nifedipine, sodium nitroprusside, liposome, leydig cells , steroidogenesis

Abstract

The purpose of this study was to look into the effect of nifedipine on the activity of Leydig cells. reduction by liposomes containing nifedipine and sodium nitroprusside by measuring the functional characteristics of Leydig cells in vitro. There were two main groups created; the first received treatment with regular nifedipine - sodium nitroprusside , and the second received treatment with liposomally encapsulated nifedipine - sodium nitroprusside. Nifedipine  concentration was in 20 µl and SNP concentration was in 20, 40, 60, 80, and 100 µl, respectively. A positive control group and a negative control group served as additional controls.

The results of Leydig cells revealed that nifedipine had a negative effect on inhibiting the activity of Leydig cells in vitro, steroidogenesis. It was also discovered that SNP had a positive stimulatory effect on Leydig cells at low concentrations.

The current study found that liposomes containing nifedipine - sodium

nitroprusside reduced nifedipine negative side effects on leydig cells and steroidogenesis, while also improving steroid activity in Leydig cells.

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Published

2023-12-01

Issue

Vol. 2 No. 2 (2023)

Section

Articles