Histopathological Study of Topical Effect of Doxycycline versus Fusidic Acid Treated Streptococcus-Induced Dermatitis in Mice: A randomized study

Abstract

Streptococcus bacteria, particularly Streptococcus pyogenes (Group A Streptococcus), are significant pathogens responsible for a variety of skin infections, including impetigo, cellulitis, erysipelas, and more severe conditions like necrotizing fasciitis and streptococcal toxic shock syndrome. These infections often present with symptoms such as inflammation, redness, and irritation of the skin, collectively known as dermatitis. which degrade host tissues and evade the immune system. doxycycline, a broad-spectrum antibiotic, is also used due to its ability to inhibit bacterial protein synthesis, thereby halting bacterial growth and multiplication. Fusidic acid, another antibiotic, is particularly effective against Gram-positive bacteria like S. pyogenes, and it has demonstrated high sensitivity in treating these infections. Its anti-inflammatory properties further enhance its efficacy in reducing inflammation associated with skin infections. This study has been conducted in order to evaluate the therapeutic efficacy of doxycycline by compare with fusidic acid. The focus is on their roles as an antibiotic and anti-inflammatory agents in treating mice with dermatitis caused by Streptococcus bacteria.
This study found that groups G3 (DOXY + VAZ), G5 (FUS), and G6 (DOXY + FUS) showed the most significant changes in their immune parameters, including LYMP and NEUT ratios, IL-6 levels, and CRP levels. These findings implied that these groups\' therapies were quite successful in modifying their immune responses. Conclusion: Doxycycline is a potentially effective treatment for streptococcal dermatitis due to its dual roles as an antibiotic and an anti-inflammatory. Its capacity to suppress important inflammatory pathways and control pro-inflammatory cytokines sets it apart from other medications like fusidic acid.